{
  "meta": {
    "api_type": "NWO Projects API",
    "version": "1.0.2",
    "licence": {
      "name": "CC0 1.0 Universal",
      "url": "https://creativecommons.org/publicdomain/zero/1.0",
      "description": "To the extent possible under law, all copyright and related or neighbouring rights have been waived worldwide to the data made available through this API."
    },
    "documentation": "https://doi.org/10.5281/zenodo.14918287",
    "release_date": "2025-08-20T00:00:00",
    "funder": "https://doi.org/10.13039/501100003246",
    "ror_id": "https://ror.org/04jsz6e67",
    "date": "2026-11-05T00:00:00",
    "count": 1,
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    "pages": 1,
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  },
  "projects": [
    {
      "project_id": "OCENW.XS23.1.128",
      "title": "DotFix – Engineering microbial quantum dot-powered carbon dioxide fixation",
      "funding_scheme_id": 4821,
      "funding_scheme": "Open Competitie ENW XS pakket 23-1",
      "department": "Exacte en Natuurwetenschappen",
      "sub_department": "Exacte en Natuurwetenschappen",
      "start_date": "2023-10-01T00:00:00",
      "end_date": "2024-11-09T00:00:00",
      "reporting_year": 2023,
      "summary_nl": "Om verdere opwarming van de aarde te voorkomen, moeten we minder fossiele brandstoffen gebruiken. In de toekomst moeten we chemicaliën en brandstof dus duurzaam maken van CO2. Biobrandstof kan geproduceerd worden van plantaardig materiaal, maar dit proces is in competitie met voedselproductie en de efficiëntie is laag. In deze studie wordt een nieuwe methode ontwikkeld waarin bacteriën die CO2 opnemen worden gekoppeld aan ‘zonnepanelen’ van nanoformaat. Het doel is om de overdracht van licht energie van de nanodeeltjes naar de CO2-opnemende bacteriën beter te begrijpen en verder te verbeteren.",
      "summary_en": "To prevent further global warning, we have to reduce our use of fossil fuels. For the future, this means we have to synthesize our chemicals and fuels sustainably from carbon dioxide. Currently, biofuels can be produced from plant material, but this process competes with food production and suffers from low efficiencies. Here, a new approach is developed, in which CO2-fixing bacteria are coupled to nanoparticle ‘solar panels’. This project aims to understand and enhance the transfer of light energy, harvested by the nanoparticles, to CO2-fixing bacteria, where the energy is used to synthesize valuable chemicals from CO2.",
      "award_amount": 49980,
      "grant_id": "https://doi.org/10.61686/FCLZC27627",
      "summary_updates": [
        {
          "submission_date": "2024-11-06T15:49:55",
          "update_en": "To enable this challenging approach, we aimed to introduce electron-transferring proteins into CO2-fixing bacteria. We successfully generated genetic constructs for this purpose. But we could not prove so far that the electron-transferring proteins are correctly produced in our engineered bacterial strains. Therefore, further work must focus on the characterization of key metabolic pathways in the CO2-fixing bacteria so that the electron-transferring proteins can be produced as intended. Over the course of this work, new genetic elements (specifically promoters) were identified and characterized. These will be used in future projects that focus on the genetic engineering of CO2-fixing bacteria.",
          "update_nl": "Om deze aanpak mogelijk te maken, wilden we elektronen-overdragende eiwitten in CO2-fixerende bacteriën introduceren. We hebben hiervoor met succes genetische constructies gegenereerd. Maar we konden tot nu toe niet bewijzen dat de elektronen-overdragende eiwitten correct worden geproduceerd in onze gemanipuleerde bacteriestammen. Daarom moet verder werk zich richten op de karakterisering van belangrijke metabolische paden in de CO2-fixerende bacteriën, zodat de elektronen-overdragende eiwitten kunnen worden geproduceerd zoals bedoeld. In de loop van dit werk werden nieuwe genetische elementen (met name promotoren) geïdentificeerd en gekarakteriseerd. Deze zullen worden gebruikt in toekomstige projecten die zich richten op de genetische manipulatie van CO2-fixerende bacteriën."
        }
      ],
      "project_members": [
        {
          "role": "Main Applicant",
          "member_id": 485766,
          "last_name": "Schada von Borzyskowski",
          "degree_pre_nominal": "dr.",
          "initials": "L.",
          "first_name": "Lennart",
          "organisation": "Universiteit Leiden||Faculteit der Wiskunde en Natuurwetenschappen||Institute of Biology Leiden - IBL",
          "organisation_id": 76828,
          "ror": "https://ror.org/027bh9e22",
          "active": true
        },
        {
          "role": "Project leader",
          "member_id": 485766,
          "last_name": "Schada von Borzyskowski",
          "degree_pre_nominal": "dr.",
          "initials": "L.",
          "first_name": "Lennart",
          "organisation": "Universiteit Leiden||Faculteit der Wiskunde en Natuurwetenschappen||Institute of Biology Leiden - IBL",
          "organisation_id": 76828,
          "ror": "https://ror.org/027bh9e22",
          "active": true
        }
      ]
    }
  ]
}